Elimination Reactions (1): Introduction And The Key Pattern
Introduction to Elimination Reactions As you’ve probably noticed by now, organic chemistry is a lot different from physics. When we’re looking to predict what reaction
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The Williamson Ether Synthesis
The Williamson Ether Synthesis In the Williamson Ether Synthesis, an alkyl halide (or sulfonate, such as a tosylate or mesylate) undergoes nucleophilic substitution (SN2) by an alkoxide to give an ether.
Read moreWrapup: The Key Factors For Determining SN1/SN2/E1/E2
SN1/SN2/E1/E2 – Summarizing The Key Factors That Determine Whether A Reaction Will Be SN1, SN2, E1 or E2 In this article we walk through the
Read moreElimination Reactions Are Favored By Heat
Elimination Reactions Are Favored By Heat Elimination reactions are often in competition with substitution reactions Generally speaking, adding heat tends to increase the proportion of elimination products relative
Read moreThe E1 Reaction
The E1 Reaction – Three Key Pieces of Evidence, and a Mechanism Last time in this walkthrough on elimination reactions, we talked about two types
Read moreThe E2 Mechanism
E2 Mechanism – How The E2 (Elimination, Biomolecular) Reaction Works Having gone through the E1 mechanism for elimination reactions, we’ve accounted for one way in
Read moreE1 vs E2: Comparing the E1 and E2 Reactions
E1 versus E2 : Comparing The E1 and E2 Reactions Now that we’ve gone through the mechanisms of the E1 and E2 reactions, let’s take
Read moreAntiperiplanar Relationships: The E2 Reaction and Cyclohexane Rings
Antiperiplanar Relationships Between C-H And The Leaving Group: The E2 Reaction and Cyclohexane Rings Here we come to a very testable application of the E2 reaction
Read moreBulky Bases in Elimination Reactions
Elimination Reactions Using “Bulky Bases” – When The Zaitsev Product Is Minor We’ve recently talked about Zaitsev’s rule in elimination reactions, and how the transition
Read moreComparing the E1 vs SN1 Reactions
The Important Role of The Counter-Ion In Determining E1 vs SN1 With tertiary alckyl halides, E1 will generally be favored over SN1 when heat is
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