Nucleophilic Acyl Substitution (With Negatively Charged Nucleophiles) Yes, there are a lot of reactions of carboxylic acid derivatives to learn! In this article we’ll explore
Read moreQuantifying The Basicity Of Amines, Using “The pKa Of The Conjugate Acid”, a.k.a. “pKaH” How do you measure the basicity of an amine? Case in point:
Read more5 Key Amine Basicity Trends What are the most important factors that affect the basicity of amines? Here are 5 key trends. Basicity increases with
Read moreA Puzzle In The Basicity Of Some Disubstituted Aromatic Amines We’ve seen that several key factors influence the basicity of amines – charge, resonance, inductive
Read moreNucleophilicity Of Amines The relative nucleophilicity of amines doesn’t get a lot of coverage in many organic chemistry courses, but if we’re going to cover
Read moreCarboxylic acids… are acids. I know that seems obvious. But it’s a near certainty that students taking Org 2 for the first time will forget
Read moreAn Introduction to Acid Base Reactions In Organic Chemistry Now that we’ve described how to figure out where the electrons are in a molecule, the
Read moreBasicity In Organic Chemistry: Some Basicity Trends Today we’ll look at a simple periodic basicity trend across the periodic table and extrapolate from it some
Read moreAcidity Trends In Organic Molecules Here, we’ll review the key trends that affect acidity, which all have the common effect of stabilizing negative charge (or more broadly,
Read moreFive Key Factors That Affect Acidity Today we’ll talk about what’s behind the trends in acidity for different molecules and discuss the most important factors
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