Reaction Friday

Reaction Friday: Friedel Crafts Acylation

Reaction Friday: Friedel Crafts Acylation

March 2, 2012

Today’s Reaction Friday is about the Friedel Crafts acylation of benzene and other aromatics, an important example of electrophilic aromatic substitution. One thing I forgot to say at the bottom is that there’s several different ways of showing how the acyl halide is activated by Lewis acid – the convention I drew is common, but [...]

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Reaction Friday: Formation of Acetals from Ketones

Reaction Friday: Formation of Acetals from Ketones

February 24, 2012

Today’s video is about the formation of acetals from aldehydes and ketones, an important method for the protection of the carbonyl group. One thing I forgot to mention in the video is that the reaction is an equilibrium – choosing alcohol as the solvent ensures that the equilibrium will be driven towards formation of the [...]

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Reaction Friday: Addition of Grignard Reagents to Ketones

Reaction Friday: Addition of Grignard Reagents to Ketones

February 18, 2012

Grignard reagents are very useful carbon-based nucleophiles and will readily form carbon-carbon bonds with carbonyl compounds. Here the reaction of Grignard reagents with ketones is described, along with several examples and a detailed mechanism. Have a great weekend! Related Posts:Reaction Friday: Formation of Acetals from KetonesReaction Friday: Friedel Crafts AcylationReagent Friday: Grignard Reagents

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Reaction Friday: Oxymercuration of Alkenes using Hg(OAc)2 and NaBH4

Reaction Friday: Oxymercuration of Alkenes using Hg(OAc)2 and NaBH4

February 11, 2012

Reaction Friday is back!!! Today’s video is on a commonly encountered reaction for making alcohols, the oxymercuration of alkenes using Hg(OAc)2 and water, followed by reduction with NaBH4. Thanks to all of those who’ve made helpful comments on making videos. Related Posts:Reaction Friday: Formation of Acetals from KetonesReaction Friday: Addition of HBr to alkenesReaction Friday: [...]

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Reaction Friday: Addition of HBr to alkenes

Reaction Friday: Addition of HBr to alkenes

January 21, 2012

The addition of HBr to alkenes is the focus of today’s video. Fast forward to the fifteen seconds at the end for maximum awkwardness. I am an idiot when it comes to this stuff. Is making videos supposed to be brutally fricking hard? I don’t know how Gary Vaynerchuk and Salman Khan do it. Thanks for [...]

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Reaction Friday: Free-radical chlorination of alkanes

Reaction Friday: Free-radical chlorination of alkanes

January 13, 2012

One of the new things I wanted to do this year was to start doing videos. Since I was starting to run out of reagents to talk about for Reagent Friday, one thought was to start talking about reactions instead – and maybe make a video for each. So today starts a new experiment: Reaction [...]

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