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Alcohols – Acidity and Basicity

Acid-Base Reactions Of Alcohols Alcohols are mild acids.  Typical aliphatic (i.e. “alkyl”) alcohols such as ethanol, isopropanol, and t-butanol have a pKa of about 16-18, making

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The Williamson Ether Synthesis

The Williamson Ether Synthesis In the Williamson Ether Synthesis, an alkyl halide (or sulfonate, such as a tosylate or mesylate) undergoes nucleophilic substitution (SN2) by an alkoxide to give an ether.

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