Alcohols To Ethers via Acid Catalysis
How To Make Ethers With Alcohols And Acid Symmetrical ethers can be made from the acid-catalyzed dehydration of primary alcohols. A classic example is the
Read moreRearrangement Reactions (1) – Hydride Shifts
Rearrangement Reactions: Substitution Reactions With Hydride Shifts In this post we cover several examples of reactions where carbocations form… but then a funny thing happens.
Read moreCleavage Of Ethers With Acid
Acidic Cleavage of Ethers Can Proceed Through an SN2 or SN1 Mechanism, Depending On The Structure Ethers do not undergo very many reactions. One key
Read moreIn Speech, Obama Expresses Concern Over Growing Electron Inequality
WASHINGTON – In a speech at a black-tie meeting of the Periodic Table of the Elements last night, President Obama called on all atoms to share their
Read moreEpoxides – The Outlier Of The Ether Family
Properties and Synthesis of Epoxides Epoxides (oxiranes) are cyclic ethers that have unusually high reactivity due to ring strain (about 13 kcal/mol). The 3-membered ring
Read moreOpening of Epoxides With Acid
Opening Epoxides With Aqueous Acid Epoxides can undergo ring-opening with nucleophiles under acidic conditions. In this reaction, the epoxide oxygen is protonated first, making it
Read moreEpoxide Ring Opening With Base
Ring-opening of epoxides with basic nucleophiles Epoxides are cyclic ethers with considerable ring strain (about 13 kcal/mol) Epoxides undergo reaction with nucleophiles under basic conditions
Read moreOn Cats, Part 4: Enantiocats
A few weeks ago we moved away from our old neighborhood where I first saw Sawhorse Cat. However a few days ago my friend Walter
Read moreMaking Alkyl Halides From Alcohols
Making Alkyl Halides From Alcohols In today’s post we show that treating alcohols with HCl, HBr, or HI (which all fall under the catch-all term
Read moreTosylates And Mesylates
All About Tosylates and Mesylates By themselves, alcohols are poor leaving groups since the hydroxide ion (HO-) is a strong base The OH group can
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