EAS Reactions (3) – Friedel-Crafts Acylation and Friedel-Crafts Alkylation
Friedel Crafts Alkylation and Acylation Aromatic rings will form C-C bonds when treated with alkyl or acyl halides in the presence of a strong Lewis
Read moreFriedel Crafts Alkylation and Acylation Aromatic rings will form C-C bonds when treated with alkyl or acyl halides in the presence of a strong Lewis
Read moreWhy Alkylation Of Amines (aka “The Williamson Ether Synthesis, But For Amines” ) Usually Doesn’t Pan Out Making a more-substituted amine from a less-substituted amine
Read moreThe Intramolecular Friedel-Crafts Reaction We explore the intramolecular Friedel-Crafts reaction in this post. But first, a very quick refresher on intramolecular reactions in general. Table
Read moreNucleophilic Aromatic Substitution (NAS) In many ways, nucleophilic aromatic substitution is the mirror opposite of electrophilic aromatic substitution. In Nucleophilic Aromatic Substitution, an electron-poor aromatic ring
Read moreKinetic Versus Thermodynamic Control In Addition of HBr to Dienes: 1,2- and 1,4- Addition In today’s post we’ll discuss 1,2- and 1,4- addition to dienes
Read moreMaking Substituted Amines Through Reductive Amination Direct alkylation of amines with alkyl halides is a difficult reaction to control. One alternative that works extremely well
Read moreIn this article we’ll discuss nucleophilic aromatic substitution, but with a new twist; a nucleophilic aromatic substitution that passes through a strange-looking intermediate called an
Read moreAll About Mutarotation The OH group on C-1 of sugars can have two possible configurations. This gives rise to two stereoisomers (called “anomers”) : the
Read moreThe carbon adjacent to an aromatic ring – the “benzylic” carbon – can participate in several useful and interesting reactions. Today we’ll provide examples and
Read moreThermodynamic vs Kinetic Products In Purchasing Decisions (And Addition To Dienes) A post about getting what you pay for, and how that translates to “kinetic
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