The Amide Functional Group: Properties, Synthesis, and Nomenclature
Synthesis, Nomenclature, and Properties Of The Amide Functional Group In this post, we’ll try to provide a broad overview of amides. We’ll provide a brief
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Basicity of Amines And pKaH
Quantifying The Basicity Of Amines, Using “The pKa Of The Conjugate Acid”, a.k.a. “pKaH” How do you measure the basicity of an amine? Case in point:
Read more5 Key Basicity Trends of Amines
5 Key Amine Basicity Trends What are the most important factors that affect the basicity of amines? Here are 5 key trends. Basicity increases with
Read moreThe Mesomeric Effect And Aromatic Amines
A Puzzle In The Basicity Of Some Disubstituted Aromatic Amines We’ve seen that several key factors influence the basicity of amines – charge, resonance, inductive
Read moreNucleophilicity of Amines
Nucleophilicity Of Amines The relative nucleophilicity of amines doesn’t get a lot of coverage in many organic chemistry courses, but if we’re going to cover
Read moreAlkylation of Amines (Sucks!)
Why Alkylation Of Amines (aka “The Williamson Ether Synthesis, But For Amines” ) Usually Doesn’t Pan Out Making a more-substituted amine from a less-substituted amine
Read moreReductive Amination
Making Substituted Amines Through Reductive Amination Direct alkylation of amines with alkyl halides is a difficult reaction to control. One alternative that works extremely well
Read moreThe Gabriel Synthesis
The Gabriel Synthesis For Making Primary Amines We’ve seen previously that it’s hard to *usefully* build amines through the SN2 reaction, because once amines start
Read moreSome Reactions of Azides
Azide Ion: Structure, Properties, and Substitution Reactions Table of Contents The Azide Ion Is A Great Nucleophile Organic Azides As “Masked” Amines Exploding On The
Read moreThe Hofmann Elimination
The Hofmann Elimination Of Alkylammonium Salts: Examples and Mechanism The Hofmann Elimination is an elimination reaction of alkylammonium salts that forms C-C double bonds [pi
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