Intramolecular Friedel-Crafts Reactions
The Intramolecular Friedel-Crafts Reaction We explore the intramolecular Friedel-Crafts reaction in this post. But first, a very quick refresher on intramolecular reactions in general. Table
Read moreReactions of Aromatic Molecules
Nucleophilic Aromatic Substitution (NAS)
Nucleophilic Aromatic Substitution (NAS) In many ways, nucleophilic aromatic substitution is the mirror opposite of electrophilic aromatic substitution. In Nucleophilic Aromatic Substitution, an electron-poor aromatic ring
Read moreNucleophilic Aromatic Substitution (2) – The Benzyne Mechanism
In this post we’ll discuss nucleophilic aromatic substitution, but with a new twist; a nucleophilic aromatic substitution that passes through a strange-looking intermediate called an
Read moreReactions on the “Benzylic” Carbon: Bromination And Oxidation
The carbon adjacent to an aromatic ring – the “benzylic” carbon – can participate in several useful and interesting reactions. Today we’ll provide examples and
Read moreThe Wolff-Kishner, Clemmensen, And Other Carbonyl Reductions
The Wolff-Kishner, Clemmensen, and Other Fun Reductions In this post we go through 4 ways of reducing C=O to CH2 including: The Wolff-Kishner reaction The
Read moreMore Reactions on the Aromatic Sidechain: Reduction of Nitro Groups and the Baeyer Villiger
Here we cover three new reactions of aromatic substituents: reduction of nitro groups to amines, protection of amines as amides, and the Baeyer-Villiger oxidation of
Read moreAromatic Synthesis (1) – “Order Of Operations”
Planning An Aromatic Synthesis: Putting Reactions In The Right Order When planning a synthesis of simple aromatic compounds, it’s not enough to pick the right
Read moreSynthesis of Benzene Derivatives (2) – Polarity Reversal
Synthesis of Benzene Derivatives: Converting ortho-,para- directors into meta- directors and vice versa. In planning the synthesis of simple benzene derivatives and other aromatic compounds,
Read moreAromatic Synthesis (3) – Sulfonyl Blocking Groups
The Sulfonyl Blocking-Group Strategy For Synthesis of Aromatic Molecules Or, how to just get the “ortho” product without any para- . Table of Contents Why
Read moreBirch Reduction
Birch Reduction of Electron-Rich and Electron-Poor Aromatic Molecules – Examples and Mechanisms The Birch Reduction is a process for converting benzene (and its aromatic relatives)
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