…Hamlin, Marcel Swart, F. Matthias Bickelhaupt ChemPhysChem 2018, 19 (11), 1315-1330 DOI: 1002/cphc.201701363 A more recent paper computationally examining the effects of various variables on SN2 reaction energetics. Solvolytic Displacement…
Read more…can then make hypotheses, and test them. The hypotheses that survive experimental testing eventually become known as “laws”, although they are really just very strong theories that have not been…
Read more…recent offering of massively open online courses (MOOC’s) in the fall. If the type of thinking required for solving the types of problems encountered in organic chemistry can be taught…
Read more…question when understanding a new reaction: where are the electrons in our starting materials? 2. The Two Reactive Partners In A Substitution Reaction Are An Electron-Rich “Nucleophile” And An Electron-Poor…
Read more…difficult organic chemistry is. I let myself get taken in by the horror stories around the first exam and did substantially worse on the first exam than I should have…
Read more…are three examples of nucleophilic substitution reactions. What’s the pattern? In each case, we’re breaking a bond at carbon, and forming a new bond at carbon. (and yes, salts form…
Read more…so they end up being common exam problems. See if you can draw the key curved arrow to show the rearrangement in this cyclic example: Click to Flip Here’s another…
Read more…The Mechanism Of Alkyl Shift Reactions Example of An SN1 With Alkyl Shift Ring-Expansion Reactions Also Involve Alkyl Shifts Notes 1. Alkyl Shifts Can Lead To More Stable Carbocations, Too…
Read more…it does! 4. Examples Of The E1cB Mechanism In Introductory Organic Chemistry: The Aldol Condensation Probably the most commonly encountered example of the E1cB mechanism in introductory organic chemistry is…
Read moreElimination Reactions (E1) That Occur With Rearrangements – Hydride Or Alkyl Shifts Where there are carbocations (see last post), rearrangement reactions are never far behind. Our old friends have come…
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