TsCl (p-toluenesulfonyl chloride) And MsCl (methanesulfonylchloride) As Reagents In Organic Chemistry In a blatant plug for the Reagent Guide, each Friday I profile a different reagent
Read moreProtonation and Deprotonation: How They Affect Reactivity One thing has been missing from our discussion of acid-base reactions. Who cares? What does it matter that
Read moreContinuing from Part 1, today I’ll cover the remaining 3 classes of mechanistic pathways for the reactions of anionic nucleophiles with carbonyl compounds, using the
Read morePretty much every reaction in organic chemistry boils down to “nucleophile attacks electrophile”.
Read moreI put together this summary sheet for the reaction of nucleophiles with carbonyls (click for larger image, see link to downloadable PDF below). It summarizes the two key concepts that are important to understand for these reactions: the effect of electronic and steric factors on nucleophilic addition.
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