Tosylates And Mesylates
All About Tosylates and Mesylates By themselves, alcohols are poor leaving groups since the hydroxide ion (HO-) is a strong base The OH group can
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Deciding SN1/SN2/E1/E2 (2) – The Nucleophile/Base
SN1 / SN2 / E1 / E2 The Nucleophile / Base This article assumes you understand the mechanisms of the SN1/SN2/E1 and E2 reactions. For
Read moreOrganic Chemistry For the MCAT
Many students taking organic chemistry one day plan to write the Medical College Admission Test (MCAT). A common question students have for me is what
Read moreSN1 vs E1 and SN2 vs E2 : The Temperature
SN1 vs E1, and SN2 vs. E2: The Role Of Heat This article assumes you understand the mechanisms of the SN1/SN2/E1 and E2 reactions. For
Read moreDeciding SN1/SN2/E1/E2 – The Solvent
Secondary Alkyl Halides With Strongly Basic Nucleophiles. The “Ask Your Instructor” Edition In the previous four articles in this series, we covered how to identify where
Read moreWrapup: The Key Factors For Determining SN1/SN2/E1/E2
SN1/SN2/E1/E2 – Summarizing The Key Factors That Determine Whether A Reaction Will Be SN1, SN2, E1 or E2 In this article we walk through the
Read moreTwo Elimination Reaction Patterns
A Tale of Two Elimination Reaction Patterns Like I said in the introduction to substitution reactions, organic chemistry is an empirical, experimental science. We make
Read moreNucleophilic Substitution Reactions – Introduction
Introduction to Nucleophilic Substitution Reactions Today starts a new series of posts on walking through one of the key classes of reaction in organic chemistry:
Read moreTwo Types of Nucleophilic Substitution Reactions
Comparing Two Nucleophilic Substitution Reactions That Clearly Have Different Mechanisms Experiments tell us that nucleophilic substitution reactions generally fall into two main groups: In one group: The reaction
Read moreThe SN2 Mechanism
The SN2 Reaction Mechanism Having gone through the two different types of substitution reactions, and talked about nucleophiles and electrophiles, we’re finally in a position
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