Why the SN2 Reaction Is Powerful
SN2 Reaction Examples To Give Alcohols, Ethers, Thiols, Sulfies, Alkynes, and More. Having gone through the mechanism of the SN2 reaction, let’s take a second
Read moreSN2
The SN1 Mechanism
The SN1 Reaction Mechanism There are two important classes of nucleophilic substitution mechanisms – the SN1 and SN2 mechanisms (See article – Two Types of
Read moreThe Conjugate Acid Is A Better Leaving Group
Adding Acid Increases Leaving Group Ability Sure, it’s one thing to recognize halogens (Cl, Br, and I) as having high leaving group ability, as well
Read moreComparing the SN1 and SN2 Reactions
Comparing the SN1 and SN2 Reactions In nucleophilic substitution reactions, a bond between carbon and a leaving group (C–LG) is broken, and a new bond
Read moreWhat Makes A Good Leaving Group?
Good Leaving Groups Are Weak Bases A leaving group (a.k.a. “nucleofuge”) is the new Lewis base that is generated in various substitution and elimination reactions when
Read moreIntramolecular Reactions of Alcohols and Ethers
The Intramolecular Reactions Here’s a topic which doesn’t really fit neatly in with what we’ve discussed before but it’s essential to any discussion of alcohols
Read moreWittig Reaction
The Wittig Reaction: A Useful Method For Converting Aldehydes and Ketones To Alkenes Some time ago, we learned how to turn alkenes into carbonyls via
Read moreSOCl2 Mechanism For Alcohols To Alkyl Halides: SN2 versus SNi
SOCl2 Mechanism With Alcohols, With And Without Pyridine: Nucleophilic Substitution (SN2) Versus Nucleophilic Substitution With Internal Return (SNi) Most of the time, the reaction of
Read moreSteric Hindrance is Like a Fat Goalie
Steric Hindrance In Nucleophilic Substitution Reactions Sportswriter Todd Gallagher asked a question that every hockey fan has probably asked at one point. “Could a morbidly
Read moreThionyl Chloride (SOCl2)
Thionyl Chloride, SOCl2 – Reaction With Carboxylic Acids to Give Acid Halides Thionyl chloride (SOCl2) is a useful reagent for converting carboxylic acids to acid chlorides.
Read more